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Épuiser vs. fatiguer

The French verbs épuiser and fatiguer both relate to making someone tired, but they have subtle differences in intensity and usage.

Épuiser

B1
Épuiser means to exhaust completely, to drain all energy or resources. It implies a more intense and thorough state of tiredness.
Le marathon a épuisé les coureurs.
(The marathon exhausted the runners.)
Ce projet a épuisé toutes nos ressources financières.
(This project has exhausted all our financial resources.)
La canicule m'a complètement épuisé.
(The heatwave has completely exhausted me.)

Fatiguer

A2
Fatiguer means to tire out or make weary. It suggests a more general state of tiredness that may not be as severe as épuiser.
Le long trajet en voiture a fatigué les enfants.
(The long car journey tired out the children.)
Ce travail me fatigue beaucoup.
(This work tires me out a lot.)
Les exercices de mathématiques ont fatigué les élèves.
(The math exercises tired the students.)

Summary

While both épuiser and fatiguer relate to causing tiredness, épuiser implies a more severe, complete exhaustion of energy or resources, whereas fatiguer indicates a more general state of being tired or worn out. Épuiser is often used in more extreme situations, while fatiguer is more common in everyday contexts.